Efficacy of sodium diethyldithiocarbamate (dithiocarb) in acute nickel carbonyl poisoning.
نویسنده
چکیده
A brief historical resume is presented on the use of dithiocarbamates for the treatment of persons exposed to nickel carbonyl. The specificity of the treatment is demonstrated in an industrial accident in which four men were simultaneously exposed to nickel carbonyl vapors. Three of the men received dithiocarb within 24 hours after exposure and the fourth was hospitalized by his family physician and treated for bronchopneumonia with antibiotics and without benefit of dithiocarb. The three workmen who received dithiocarb became symptomless and returned to work within 72 hours after exposure. The fourth man who had not received dithiocarb died within five days after exposure.
منابع مشابه
Use of sodium diethyldithiocarbamate in the treatment of nickel carbonyl poisoning.
This presentation is primarily concerned with the use of sodium diethyldithiocarbamate (Dithiocarb) in the treatment of acute nickel carbonyl poisoning. Reference will be made to earlier studies pertaining to diagnosis in relation to treatment. In addition, recent studies will be briefly considered on the administration of Dithiocarb to rats developing tumors following the muscular implantation...
متن کاملTherapeutic properties of sodium diethyldithiocarbamate: its role as an inhibitor in the progression of AIDS.
The therapeutic history of sodium diethyldithiocarbamate (dithiocarb) is briefly reviewed. Dithiocarb was discovered serendipitously in our laboratory 35 years ago for the specific treatment of nickel carbonyl poisoning. Since that time, the therapeutic efficacy of dithiocarb has been reported for many disorders, including: nickel, cadmium, thallium, copper, and mercury poisonings, experimental...
متن کاملChelation therapy in nickel poisoning.
For the treatment of acute poisoning from the inhalation of nickel carbonyl, sodium diethyldithiocarbamate (Dithiocarb) has proved to be a specific antidote; tetraethylthiuram (Antabuse) is effective to a lesser degree; d-penicillamine and dimercaprol (BAL) have limited therapeutic value. For the treatment of nickel eczema and dermatitis, favorable response has been obtained by placing patients...
متن کاملClinical response to therapeutic agents in poisoning from mercury vapor.
Exposure to mercury vapors for an hour per working day over a period of 13 years produced in a thermometer manufacturer severe signs and symptoms of mercury poisoning. Complete disability developed insidiously over the last six months of employment. During the first two months of observation, the patient was treated in succession with three chelating agents: 2,3-dimercapto-l-propanol (BAL), D-p...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Annals of clinical and laboratory science
دوره 9 1 شماره
صفحات -
تاریخ انتشار 1979